Structural biology-inspired musings

During each week of protein structure releases at the PDB, there are typically a few of interest to me, sometimes ones of considerable inter...

G protein-coupled receptors are a very large superfamily of transmembrane proteins that transmit signals into cells. They all have seven me...

In my last post, I mentioned how highly homologous TRP channels respond in opposite ways to temperature changes. A clue to this paradox came...

How do we know when a room is hot or cold? The family of transient receptor potential (TRP) ion channels senses general stimuli such a...

I decided to start this blog up again as a fully-specialized blog about science, leaning strongly toward discussions of structural biology. ...

First an update on the last one: The structure of EF-Tu on the ribosome has now been solved with a non-hydrolyzable guanine nucleotide, in t...

Like the last speculation, this one involves the ribosome. In particular, the two elongation factors that in bacteria are known as EF-Tu and...