Then why did I decide to start blogging again at all? Well, I'm finding that as I read through the many published articles on structural biology, I often have hypotheses and hunches that I could never publish, and that pertain to fields so far apart in terms of the underlying biology that I couldn't possibly study all of them. I felt I needed a place to "air" these ideas, where anyone who wants to read them (maybe even some people who work on the relevant systems) can do so.
While I sometimes have these ideas about other areas of science, I can't state them nearly as precisely as my hypotheses regarding protein structure. Therefore they're best suited to in-person discussions with me at a bar or something like that. Plus, being visual, I find that ideas about protein structure are more intuitive to describe, too.
An example of the why I want a blog like this--it turns out that the metal ion that I hypothesized here to trigger GTP hydrolysis in transcription factors has since been found to exist(1) (at least in eIF5, which is homologous to EF-Tu and EF-G), contrary to the preliminary data I reported on in my last post, and it's virtually exactly where I predicted it. It took an additional four years for it to be found, though, probably because the resolution of the ribosome-bound elongation factor structures was too low to observe it.
If you notice, I'm also moving to a more proper citation format. This post only has one, but upcoming posts may have many, and I want to make sure I'm properly referencing the publications on which I base my hypotheses.